A woman with Down syndrome showed no cognitive decline well into her 60s despite having Alzheimer's disease markers, according to UC Irvine neuroscientists. This case study may help scientists understand why some individuals with Down syndrome remain mentally sharp despite the presence of beta amyloid plaques. Researchers aim to uncover genetic or lifestyle factors that could benefit others with similar conditions. Elizabeth Head, PhD, and her team at UC Irvine are focused on identifying targets to slow or prevent Alzheimer's progression in people with Down syndrome.