Frank Hsu, MD, PhD, the Denny and Betty Tsai Endowed Chair in Neurological Surgery at UCI Health, reflects on shaping a comprehensive, subspecialty-driven neurosurgery program grounded in collaboration, academic rigor, and steady innovation.

Since joining UCI Health in 2012 and assuming departmental leadership shortly thereafter, Hsu has helped guide the program through a period of significant growth, expanding faculty depth across trauma, spine, vascular, functional and skull base neurosurgery while strengthening residency and fellowship training.

In this conversation, he discusses building a culture that prioritizes teamwork over ego, developing multidisciplinary programs in partnership with neurology, orthopedics and otolaryngology, and advancing minimally invasive approaches such as focused ultrasound for essential tremor and Parkinson’s disease. He also outlines how the UCI Health expansion into Irvine and affiliated community hospitals is enhancing access to complex stroke, trauma, and tertiary neurosurgical care across the region.

This episode offers an inside look at how advanced neurosurgery evolves, through deliberate recruitment, evidence-based innovation and incremental progress in some of medicine’s most challenging diseases.

Topics Discussed

• Multimodality monitoring in traumatic brain injury
• Expanding subspecialty expertise across trauma, spine, vascular and functional neurosurgery
• Comprehensive spine collaboration with orthopedics, neurology, pain and rehab
• Growth of residency and fellowship programs
• Focused ultrasound for essential tremor and Parkinson’s disease
• Expansion across Irvine and community hospitals
• Building a collaborative neurosurgery culture
• Managing stroke volume in a growing region
• Evidence-based adoption of robotics and minimally invasive techniques
• Incremental advances in glioblastoma survival
• Academic leadership in Orange County’s only academic medical center